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Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene

doi:10.1124/jpet.114.218735

* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies ** Based on the treatment policy estimand: estimated efficacy regardless of whether patients stayed on treatment or took other weight loss therapies About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program)

Receptor Pharmacology and Signaling Pathways : Characterizing activation of amylin/calcitonin receptors, downstream signaling, and functional readouts in different cell systems

doi: 10.1016/S0140-6736(21)01751-7