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Activity was increased by in vitro exposure of cells to interleukin-2

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skin leakage was equivalent and pain scores were improved with the 4-mm needle

Additionally, sarcosine serves as a substrate for GlyT1 but does not interact with GlyT2, highlighting key pharmacological differences between these transporters (Zafra et al

Both siblings had the same homozygous 22-bp deletion in the cytoplasmic domain of the GHR, resulting in a frameshift and premature stop codon The resultant GHR was truncated at amino acid 449 (GHR1-449) after Box 1, the JAK2 binding domain of the receptor, and functional studies in HEK293 and Chinese hamster ovary cells showed a selective loss of STAT5 signaling in cells expressing GHR1-449 (Milward et al., 2004)