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The authors explicitly stated that the study was "not intended to provide guidance on the sublingual dosing of semaglutide in humans." Extrapolating from a rat study on a different peptide to human use of tirzepatide drops involves multiple leaps of scientific faith that responsible review cannot endorse

High dose: severe injuries or serious arthritis (only under the supervision of a veterinarian) Capsule-based protocols also make use of: Dogs more than 75 lbs: 500 mcg per day to twice per day

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(10 g or 10 ng/kg/day), topical (1.0 g in cream), or per-oral (0.16 g/mL in drinking water) over 90 days and described directional improvements across biomechanical, functional, macroscopic, and histological endpoints, though specific effect sizes and p-values are not reported in the abstract