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Free Radic Biol Med 95:2742 Creissen G, Firmin J, Fryer M, Kular B, Leyland N, Reynolds H, Pastori G, Wellburn F, Baker N, Wellburn A, Mullineaux P (1999) Elevated glutathione biosynthetic capacity in the chloroplasts of transgenic tobacco plants paradoxically causes increased oxidative stress

the excess free radicals deplete glutathione reserves, and the decreased ATP production slows glutathione replenishment, ultimately resulting in chronic glutathione deficiency [8]

In a randomized, double-blind, placebo-controlled clinical study in 67 patients with severe traumatic brain injury, intravenous administration of dexanabinol (48 mg or 150 mg) within 6 hours of injury resulted in lower intracranial pressure and a reduced number of hypotensive episodes, indicating improvements in cerebral edema

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