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the second class comprises comediator SMADs, of which only Smad4 has been identified in mammals

9 A systematic review of 14 hospital-based observational studies in older adults found an ADE to occur more often with an increased number of medications

Atlanta, GA: Centers for Disease Control and Prevention (US)

In addition, the second-generation PI carfilzomib and the only oral drug ixazomib have been approved, and if they can demonstrate the same antitumor efficacy as BTZ, then PN may become a minor issue in the treatment of MM, resulting in an improved quality of life for the patient and a reduced financial burden (Perrot et al., 2024