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Pregnancy Teratogenic Effects: Pregnancy Category C Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy or in women of childbearing potential requires that the anticipated benefits be weighed against the possible hazards to the mother and embryo or fetus

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PMID: 22254102

Especially smokers should thus avoid cyanocobalamin and use other forms of B12 instead this will keep their exposure to cyanide down, and will even help with detoxification