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Acknowledgements This study was supported by National Natural Science Foundation of China (82074355, 82074441) and Shanghai Municipal Health Commission (GWIV-28)

When cells use NAD+, they leave behind some NAM, and the salvage pathway can cycle it back to the beginning of the process

Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses

Lithium, a mood stabilizer widely used in bipolar disorder, is a potent inhibitor of GSK3 and has been shown to enhance the efficacy of some other antidepressants in MDD (152)