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GPX4 activity assessment PC12 cells expressing GPX4-FLAG were pretreated with DA and FeCl 3 solution for 6 hours

It was almost like a Trojan horse

A Mendelian randomization analysis established causal links between specific GM and ALD, identifying two risk factors and one protective factor

Under basal homeostatic conditions, Nrf2 is sequestered in the cytoplasm through its interaction with the adaptor protein KEAP1 (Kelch-like ECH-associated protein 1), which targets Nrf2 for ubiquitination and subsequent proteasomal degradation

However, a cavity on the capsid surface at an inter-protomer interface, where we previously reported extra electron density 7 , has recently been identified as potentially druggable, with micro-molar binding for a benzene-sulfonamide derivative 8