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Previous research has also highlighted bioenergetic defects and disturbances in mitochondrial calcium homeostasis in NPCs carrying other mutations associated with LS (Ma et al., 2015

Patients were classified as severe asthma defined by 2014 European Respiratory Society/ATS guidelines (41)

Patients using Nebido did report an initial qualitative improvement in their symptoms, however as the weeks went on they noticed a dip or trough, with a return of their symptoms of low testosterone

This enzyme plays an important role in cancer as over-expression results in silencing of tumor-suppressing genes, and it is thus regarded as an attractive target for therapeutic interventions