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Conclusion: Data suggest a nonlinear decrease in mortality risk as circulating 25(OH)D increases, with ."(17) optimal concentrations 75-87.5 nmol/L [30-46 ng/mL] You can see this in their Figure, which is nominally U-shaped, with the sweet spot at ~31 ng/mL, although the CIs don't rule out the possibility that mortality merely FLATTENS at 31 ng/mL and above, rather than reaching a true trough there with risks getting worse at higher values: Caption: "Summary nonlinear dose-response relation (dotted lines: 95% CI) from the best-fitting random-effects model, between an increase in the concentration of 25(OH)D (ng/mL) with respect to reference values and overall mortality RR

A.PoggiM.KnaufC.BastelicaD.et al (2007)

Moreover, reducing drug dosage still achieved significant cytotoxic effects

Global burden of stroke and risk factors in 188 countries, during 19902013: A systematic analysis for the global burden of disease study 2013