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ROS lead first to oxidation of protein thiols to Cys sulfenic acids as unstable intermediates (R-SOH) (Figure 3)

Besides inhibiting the Xc- antiporter, erastin is also an activator of the mitochondrial voltage-dependent-anion channel (VDAC) by reversing the inhibitory effect of tubulin on VDAC, thus increasing oxidative phosphorylation, ATP, ROS production and mitochondrial membrane permeabilization

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When the equilibrium is directed towards fusion, mitochondria are interconnected, net-like or aggregated in small regions of the cell