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Despite this, the proinflammatory effects of TNF- in bFLS on metabolic reprogramming have been poorly studied

The application of exogenous SL modified the gene expression profiles in a clear concentration-dependent manner: compared to the DS group, the DS+SL0.1, DS+SL1, and DS+SL10 groups contained 2,799 (1,097 up/1,702 down), 3,661 (1,534 up/2,127 down), and 2,440 (1,134 up/1,308 down) DEGs, respectively ( Figure 2B )

All three compounds are combined in a single lyophilised preparation

doi: 10.3389/fimmu.2023.1288256 32 Wu HJEW