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doi: 10.1016/j.biopha.2020.110234, 51

Deficiencies vitamin B 12 result in problems affecting multiple systems, including hematologic, neurologic, dermatologic, ophthalmologic, cardiovascular, and renal

This positions it as a useful parallel research subject alongside dermal matrix peptides when constructing multi-target anti-aging peptide therapy frameworks

The platform uses hydrophilic interaction liquid chromatography with positive/negative ion switching to analyze 258 metabolites (289 Q1/Q3 transitions) from a single 15-min targeted liquid chromatographytandem mass spectrometry (LCMS/MS) acquisition with a 3-ms dwell time and a 1.55-s duty cycle time (Yuan et al