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Anti-inflammatory properties of NRF2 signaling have been verified in LPS-stimulated mouse microglia, where its upregulation reduced inflammatory markers (Townsend and Johnson, 2016) and astrocytic, and microglial activation were found to be significantly lower (Jing et al., 2015)

J Clin Invest 2023;133(20)

Bilirubin effects on mitochondrial disfunction Before apoptosis, there were indicators of poor mitochondrial metabolism and membrane disruptions, such as altered lipid polarity and flow, protein ordination, and oxidative status