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Specifically, murine systems lack the heterogeneous donor-recipient interactions, comorbidities (e.g., diabetes, hypertension), and immunosuppressive drug effects pervasive in clinical settings

[DOI] [PubMed] [Google Scholar] [30].Luhby AL, Cooperman JM, Pesci-Bourel A

and J.M

She is a woman of her time though and tries to be sneaky rather than demanding

The majority of Treg cells express the CD25 molecule (IL-2R receptor), which exhibits a high affinity for IL-2 and initiates CD25-mediated signaling through activation of the transcription factor STAT5 [154]