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Analysis of a metabolic dysfunction-associated steatohepatitis mouse model revealed that circadian clock disorders, characterized by reduced expression of Rev-erb, Per1, Per2 and Cry2, resulted in a loss of control over TGF- signaling, thereby promoting HSC activation and collagen deposition

Cells of the oligodendrocyte lineage and in particular OPCs could be considered the Achilles heel to oxidative stress in neurodegenerative disorders, especially due to the immense morphological change in a short time window coupled to limited defence mechanisms against stressors

Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol 2001

However, dietary effects are context-dependent

Lactobacillus reuteri ameliorates lipopolysaccharide-induced acute lung injury by modulating the gut microbiota in mice