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Picture rheumatoid arthritis as a fortress besieged by its own guards: a T-cell mediated autoimmune disease where the immune system, mistaking joint linings for foreign foes, launches unprovoked assaults [4]

135 StefanisL.EmmanouilidouE.PantazopoulouM.KirikD.VekrellisK.TofarisG

Spermidine suppresses inflammatory dc function by activating the Foxo3 pathway and counteracts autoimmunity

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

This suggests that the effects of MG extend beyond binding to GSH and involve the inhibition of GSH resynthesis and enzymes that play key roles in its synthesis, thereby promoting ferroptosis