When arbutin is applied to the skin, microbes or ultraviolet radiation (UVR) can convert it into hydroquinone (Kanlayavattanakul and Lourith, 2018)
However, because many patients already suffer from hearing damage after cisplatin cancer therapy, it is very important to find effective medications that have a therapeutic effect on existing cisplatin-induced ototoxicity
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PE was defined as hypertension (mean SBP 140 mmHg and/or DBP 90 mmHg) occurring after 20 weeks of gestation, accompanied by proteinuria (random urine protein 1 + or urine protein quantification 300 mg/24 h) or without proteinuria but with damage to one organ or system
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