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doi: 10.1016/j.ejca.2010.12.008

Preclinical studies have shown that a single injection of ketamine immediately increases the firing and burst activity of NE neurons [75]

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Monti and colleagues in Uruguay ran a double-blind crossover of 25 nmol/kg over four nights and found that although several sleep measures moved in the expected direction, none differed significantly from baseline or placebo, and where differences did reach significance for NREM and stage 2 sleep, the same differences already existed at baseline