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Intermediate hyperhomocysteinemia (fasting plasma tHcy 30-100 mol/L) is usually the result of moderate/severe vitamin B12 or folate deficiency, homozygous enzyme defects in homocysteine metabolism, or renal failure.34,57 Again, diagnosis and reversal of the respective cause should be the main priority, while most patients respond well to folate alone or in combination with B12, B6 and possibly betaine

doi: 10.1016/j.tracli.2022.09.002

5 AxarliI.DhavalaP.PapageorgiouA

All the probable outcomes hamper the overall efficiency of carrier-based targetability

Tissue Slices Figure 7 depicts the results of H&E staining of liver tissues from C57BL/6N mice fed alcohol diets for 8 weeks, using a general liquid feed and LAB