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Importantly: Neither peptide is FDA-approved for human use There are no large-scale human clinical trials validating safety or efficacy Quality and purity are often uncertain when purchased through underground or non-medical sources Despite this, BPC-157 and TB-500 are popular in bodybuilding, CrossFit, and athletic recovery spaces because of claims around faster healing and reduced downtime from injuries

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Moreover, alcoholics may experience reduced intestinal absorption of vitamin B 12 (2), and individuals with acquired immunodeficiency syndrome (AIDS) appear to be at increased risk of deficiency, possibly related to a failure of the IF-B 12 receptor to take up the IF-B 12 complex (3)

doi: 10.1210/jc.2018-00070

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