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Whereas most patients, including P3 and P4 in the current study, had a very similar and recognizable phenotype at birth, the siblings from family 1, and to a lesser extent P5, lacked most of the typical facial features at birth and in infancy, and they did not initially display pronounced skin fragility

[129] , methotrexate-loaded SLNs were prepared to enhance skin penetration and reduce keratinocyte proliferation

doi:10.1056/NEJMoa2108891

Oxidative stress is defined as an imbalance between the production of reactive oxygen species (ROS) or free radicals and antioxidant defense, which may induce tissue injury

Histone lysine methylation and acetylation usually act in a mutually antagonistic manner