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Mutation of this residue to alanine resulted in complete loss of activity consistent with a role for Arginine 130 in stabilizing the strongly nucleophilic GSH thiolate required for catalysis (Table 1)

6 Emerging flavonoid subclasses with translational promise While quercetin, apigenin, and kaempferol dominate historical discussion, several less-covered subclasses now show compelling anticancer signals together with formulation paths that address exposure limits

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International journal of clinical pharmacology research , 10 (1-2), 101107