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This is possible, but given that innate inflammation in the form of microglial activation and macrophage infiltration is a universal response to most types of CNS injury (Rivest, 2009), we would argue that it remains equally plausible that in MS microglia/macrophages are instead reacting to some persistent underlying pathological process in an attempt to limit and repair the expanding white matter damage

This frequency is enough to reverse the signs of vitamin B12 deficiency