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An alternative explanation is that inhibition of TS by folate-based agents is not durable, in spite of intracellular polyglutamation, and can be competed out by naturally occurring folates once plasma drug levels are reduced

The inhibition of these enzymes leads to oxidative stress [23,57]

[DOI] [PMC free article] [PubMed] [Google Scholar] 252.Martn-Fernndez M., Aller R., Heredia-Rodrguez M., Gmez-Snchez E., Martnez-Paz P., Gonzalo-Benito H., Snchez-de Prada L., Gorgojo ., Carnicero-Frutos I., Tamayo E., et al

Please feel free to ask any questions, no matter how small they may seem

Its important to watch closely and teach patients about these risks