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demonstrated CD38 KO, CD38 inhibitors treatment, or adeno-associated virus (AAV)-mediated endothelial CD38 knockdown can reduce blood pressure and improve vascular dysfunction in AngII-induced hypertensive mice [45]

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145 XieB.XingR.ChenP.GouY.LiS.XiaoJ.et al (2010)

ASP induced cell cycle G1 phase arrest in EC cells The KLE and Ishikawa were treated with 0.01, 0.1, and 1 mg/mL ASP extracts for 36 h, and an analysis of cell cycle prolife showed that ASP extract induced cell cycle G1 phase arrest in both cell lines (Figure 2A)

I dont think this is a problem that we can regulate ourselves out of because were always producing new designer substances, Piatkowski says