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Furthermore, the combination of VIR3434 with the small interfering RNA (siRNA) drug VIR-2218 which targets all HBV transcripts achieved an average reduction in HBsAg levels exceeding 2.5 Log10 IU/mL, with most patients reaching HBsAg levels below 10 IU/mL[31]

An increase in metHb levels and in its linkage to the RBC membrane, accompanied by ROS formation, was also found in stored RBCs for blood transfusion [30] and in exogenous H 2 O 2 -induced OS upon healthy erythrocytes [31, 32]

This observation suggests a potentially different mechanism underlying the suppressive effects of LDH inhibition in NB, it may extend beyond its recognized metabolic functions in tumorigenesis