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FIGURE 2 TABLE 1 Regulation of p53 in ferroptosis network

L., de Souza Almeida, R

doi: 10.1038/nrendo.2014.171 133

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This iron-sequestering capability is particularly important because excess free iron directly enters cells, concentrates in mitochondria, disrupts oxidative phosphorylation, catalyzes lipid peroxidation, and ultimately leads to cell death