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This impairment of the bodys self-protective mechanisms prevents effective clearance of ROS, ultimately exacerbating lung damage ( 5.3 Protease-antiprotease imbalance Under physiological conditions, a dynamic balance is maintained between proteases (which degrade tissue components) and antiproteases (which inhibit protease activity) in lung tissue

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Thus, the ligand metabolism mediated by CYP1A1 serves as an important negative feedback mechanism