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The results suggest impaired insulin response to high glucose levels in PD, which may be due to the failure of cells to enhance insulin secretion to cope with elevated blood glucose

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Although HIFs are the canonical substrates for PHD- and FIH-mediated protein hydroxylation, increasing evidence indicates that these hydroxylases may also have alternative targets

Collectively, these studies establish histone acetylation as a fundamental epigenetic mechanism sustaining glioma stem cell properties via dynamic crosstalk with histone methylation, ubiquitination, and other post-translational modifications, and highlight acetylation-centered regulatory networks as promising therapeutic vulnerabilities in GBM

In standard scientific practice, a researcher with a patent and a company tied to their research subject would be required to declare that conflict