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2.3 GABA promotes -cell proliferation and survival Loss of -cell mass due to a reduction in -cell proliferation/regeneration and accelerated -cell apoptosis are synergistic processes leading to the clinical manifestations of TID

BerdingKVlckovaKMarxWSchellekensHStantonCClarkeGet al

Cytokine 111:475480

Perhaps the closest he comes to this consideration might be his mention of nostril dilation in fearful horses, but he argues that this is the result of an association between fear and the exertions of rapid flight (Darwin, Reference Darwin1872: 130), rather than functioning to detect a source of danger

Studies have shown that clinicians are more likely to use machine-learning tools when they align with established diagnostic criteria and when the meaning of features can be explicitly understood 6