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Hormonal changes during pregnancy can trigger melasma, often referred to as the "mask of pregnancy." It may fade postpartum but can persist in some cases

Given the indispensable role of PINK1 in the initiation of mitophagy, there is the possible modification of ROS on PINK1 in the process of mitophagy 102

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No published time-course demonstrates diminishing effect, and mechanistic reviews note the absence of receptor desensitization that would predict tolerance

The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline