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Animal research suggests that the milk thistle constituent silibinin might increase plasma levels of tamoxifen and alter its conversion to an active metabolite

Lu L, Wang JR, Henderson YC, Bai S Yang J, Hu M, Shiau CK, Pan TY, Yan Y, Tran TM, Li J, Kieser R, Zhao X, Wang J, r N, Williams MD, Cabanillas ME, Dadu R, Busaidy N, Zafereo ME , Navin N, Lai SY, Gao R