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Those with heart conditions, high blood pressure, or certain mental health disorders may not be candidates for the medication

Animal studies suggest that a very high intake may cause toxicity

This shift often comes with uncomfortable symptoms such as hot flashes, night sweats, mood changes, and sleep disturbances

To address this gap, we established a human in vitro model of SORD deficiency by generating induced pluripotent stem cells (iPSCs) from fibroblasts affected individual carrying biallelic SORD mutations ( SORD c.757delG/c.316_425+165del ), and unaffected heterozygous carriers ( SORD c.757delG/wt and SORD wt/c.316_425+165del )

The 12mg designation specifies the total combined mass of the lyophilized peptides contained within that single vial