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Mamdouh AM, Lim FQ, Mi Y, Olesinski EA, Wang Y, Jasdanwala SS, Bhatia KS, Lin XX, Sapozhnikova V, Mertins P, Brown BD, Qiu Y, Letai AG, Puissant A, Kornblau SM , Krnke J, Ayoub E, Itahana K, Andreeff M, Bhatt S

Three important clinical features of FMS make us question any peripheral soft-tissue etiology of this syndrome

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Hyperpigmentation was observed when this compound got oxidized and inactivated by factors such as heat, radiation and inflammation with consequent loss of the inhibitory effect on tyrosinase

GSSCys and HEDS oxidoreductase assays Steady-state kinetics of wild-type and mutant ScGrx7 and HsGrx5 C122S in the GSSCys and HEDS assays were determined spectrophotometrically by monitoring the consumption of NADPH at 340 nm and 25 C using a thermostated Jasco V-650 UV/vis spectrophotometer 11,19,25