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Dehydration is the most common reversible cause, requiring loss of just 2% of body weight in fluids to trigger symptoms like dizziness and rapid pulse

Short chain fatty acids in human gut and metabolic health

While this finding is of great interest to the field of konzo as well as other neurodegenerative diseases, we cannot determine if the reduction in GPx3 is a result of disease or an inherent contributing factor for disease that is triggered by a micronutrient deficiency or underlying genetic variability

Specifically, FXR interacts with CRTC2, preventing its association with CREB at ATG promoters, thereby inhibiting the transcription of genes required for autophagosome initiation and lysosomal biogenesis