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Description

J Exp Med 213:15131535

In the process of hepatocellular steatosis, one of the hallmarks of MASLD is the appearance of the UPR in hepatocytes, which can inhibit mitochondrial lipid oxidation through the UPR-induced ATF-6 pathway and promote fatty acid synthesis via the PERK, ATF-6 and IRE1 signaling pathways, which together promote intracellular lipid accumulation (67,68)

the geometry is determined by steric preference of ligands and structural constraints imposed by the protein

In hot, humid regions of Africa and Asia with improper grain storage facilities, high levels of dietary AFB 1 are associated with increased risk of hepatocellular carcinoma