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Nrf2 pathway enhancement : Hydrogen activates the Nrf2 pathway more effectively when cellular antioxidant systems are properly supported by essential vitamins and minerals, creating an amplification effect on the body's endogenous antioxidant production

Apart from differential compartmentation, one possibility is that this array of enzymes guarantees robust redox homeostasis, even at the expense of redundancy, consistent with loss-of-function studies for APX and PRX isoforms in the chloroplast (Awad et al

TABLE 2 Advanced in trials Dry AMD treatments