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Tbx1 haploinsufficiency alters the brain metabolomic profile of young adult mice To visualize the effects of Tbx1 haploinsufficiency on cell metabolism across the genome, we evaluated the metabolomic and transcriptional profiles of the brains of adult Tbx1 +/ and WT mice (Group 3 in Fig S1C, Table S1) that had been treated with vB12 or with PBS (vehicle) twice a week for 4 wk starting at 4 wk of age

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By binding to G-actin, TB-500 maintains a pool of actin monomers that prevent the premature hardening of the cellular skeleton