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Early pregnancy can reduce breast cancer incidence, while delayed menopause is linked with breast cancer development ( Nutritional diet Diet may act on different biological mechanisms, such as inflammation, immunity, cell regulation factors, angiogenesis, and growth factors, in the intervention of carcinogenesis ( Molecular mechanisms involved in breast cancer development Carcinogenesis is a complex, multi-step process driven by a variety of molecular and cellular mechanisms ( Figure 2 ) ( Figure 2 In mammary epithelial cells, Bcl-2 is present in non-pregnant women and during early pregnancy, yet it is undetectable during lactation ( The expression of Bcl-2 has been shown to correlate with oestrogen receptor (ER) and progesterone receptor (PR) status in breast cancer

Jurecic R Nachtman R, Chen AJ, Jiang S, Snell V, Van NT, Andreeff M , Belmont JW

One possibility is that Cu may play role in inflammatory responses involved in atherosclerosis

With the effectiveness of thyroid hormones, superoxide formation in the mitochondrial electron transport system increases [25]

239 WienerJPet al