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135 On the other hand, Fang et al

10.1016/j.healun.2023.04.014 59

Organoid cultures for the analysis of cancer phenotypes

A-to-I RNA editing, a widespread modification in the mammalian transcriptome [57], is catalyzed by adenosine deaminases acting on RNA (ADAR), which bind to double-stranded RNA regions and mediate the deamination of adenosine (A) to inosine (I)