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elegans lifespan 55

Thalamic alterations remote to infarct appear as focal iron accumulation and impact clinical outcome

In the Phase 3 REDEFINE 1 trial, the most commonly reported adverse events included nausea, vomiting, diarrhoea, and constipation

doi:10.1186/1750-1172-3-8

Together, these findings establish that LCN2 exacerbates ferroptotic death under both basal and iron-overload conditions and that SLC22A17 is a key mediator of LCN2-driven Fe uptake, oxidative stress, and ferroptosis in osteocytes