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Patients are encouraged to discuss any previous vitamin deficiencies, sensitivities, allergies, or recent health concerns prior to treatment

Frequent missed doses may compromise treatment effectiveness, and patients experiencing difficulty maintaining their dosing schedule should discuss strategies with their healthcare provider, such as setting reminders or adjusting the injection day to better fit their routine

Regular B12 injections can help combat fatigue, improve mood, and support overall metabolic functions

doi: 10.1016/j.ymgme.2012.07.007

Early evidence for the potential efficacy of this route was published in 1999, where 18 patients with B12 deficiency treated exclusively with 712 days of 2 mg of sublingual cobalamin daily had 4 times higher B12 levels compared to pre-treatment, reaching therapeutic ranges ( There have also been further studies comparing treatment outcomes from the sublingual route to the more established IM and oral routes