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A proof-of-concept trial investigating metformin as an add-on treatment for mild or moderate SLE demonstrated that metformin down-regulated the NETs mtDNA-PDC-IFN pathway, leading to clinical improvement of SLE and reduced its reliance on prednisolone (133)

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doi: 10.1523/JNEUROSCI.19-09-03430.1999 59

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Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease