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Muscle Atrophy and Tissue Protection CGA supplementation (12.5 mg/kg) in diabetic rats significantly upregulated expression of antioxidant and metabolic genes (SOD-1, SOD-2, PGC-1, calcineurin) and improved muscle histology, indicating a protective role in diabetes-induced muscle atrophy [170]

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Human studies support these findings: A randomized controlled trial demonstrated that a six-month zinc supplementation regimen in older adults increased plasma zinc levels and decreased markers of inflammation, including high-sensitivity C-reactive protein, IL-6, MCP-1, and VCAM-1