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Radiother Oncol 120(1):48-55, 2016

Betibeglogene autotemcel is an autologous hematopoietic stem cell-based gene therapy that may increase functional adult HbA and total Hb to normal levels and eliminate dependence on regular packed red blood cell transfusions (185)

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It has been proposed that copper may enter as anionic copper ligands (CuL) or complexed with GSH (70), possibly passing through the outer mitochondrial membrane into the intermembrane space (IMS)