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(C) mRNA expression levels of mitochondria-related genes ( OPA1 , PDK1 , BIK , RRM2B , and ENDOG ) determined after cisplatin treatment by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)

The pharmacological induction of ferroptosis mainly involves inhibition of the SLC7A11-GPX4 pathway, whereas the compounds ferrostatin-1 or liproxstatin-1 exhibit strong antioxidant activities in blocking ferroptosis [85,131,132]

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Am J Obstet Gynecol 226:S973-s987

This research uncovers a new way that obesity affects cancer and suggests that drugs like Retatrutide could be used to improve cancer treatment in obese patients