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Additionally, the long-term consequences of endothelial IGF- 1R deficiency on skeletal muscle function should be explored, as chronic vascular insufficiency could eventually contribute to muscle wasting and frailty

The SLC1A5 variation then carries glutamine into the mitochondrial matrix, where glutaminase (GLS) transforms it into glutamate (Fig

The brain is inquisitively susceptible to ROS as it consumes the largest portion of oxygen and it contains high amounts of lipids and transition metals involved in the generation of hydroxyl radicals and other ROS 53

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This is accompanied by a decrease in OXPHOS that is characterized by blunted TCA cycle and reduced mitochondrial respiration