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+ -glucose transporter 2 (SGLT2), which couples the transport of the sugar with that of Na + following its electrochemical gradient created by the Na + /K + ATPase on the basolateral membrane of the tubular cells (see Figure 3B)

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Rather than combining two separate compounds, tirzepatide is a single molecule engineered to activate two receptors simultaneously

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Increased oxidative stress and ROS overproduction may cause not only endothelial dysfunction but also programmed ECs death such as ferroptosis, pyroptosis, or necroptosis that are involved in the pathophysiology of many diseases, like COPD [78]