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For IE mRNAs, a viral transactivator called VP16 plays an important role in promoting their transcription by binding to cellular factors namely the octamer-binding protein 1 (Oct1) in epithelial cells and the host cell factor-1 (HCF-1), both in epithelial and neuron cells (Herrera and Triezenberg, 2015)

Experimental studies in different animal models have demonstrated that vitamin D can influence DNA methylation patterns and induce histone modifications such as methylation and acetylation